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CLSI Releases Newborn Screening Document to Aid in the Detection of Severe Combined Immunodeficiency

Wayne, Pennsylvania, USA—May 2013—Clinical and Laboratory Standards Institute (CLSI) has released NBS06-A—Newborn Blood Spot Screening for Severe Combined Immunodeficiency by Measurement of T-cell Receptor Excision Circles; Approved Guideline. Severe combined immunodeficiency (SCID) is a lethal disorder not evident at birth. This document addresses its detection by population-based newborn screening (NBS), which uses dried blood spot (DBS) specimens to measure T-cell receptor excision circles (TREC). TREC may be used to reveal the presence of SCID, and this presymptomatic detection is required for effective treatment.

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