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CLSI to Publish 29th Edition of Annually Updated AST Supplement M100


Wayne, Pennsylvania, USAThe Clinical and Laboratory Standards Institute announces the publication of its annually updated antimicrobial susceptibility testing (AST) supplement M100—Performance Standards for Antimicrobial Susceptibility Testing, 29th ed. M100 is available as part of a package with either M02—Performance Standards for Antimicrobial Disk Susceptibility, 13th edor M07—Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 11th ed, or all three documents together.  

Melvin P. Weinstein, MD, chairholder of M100 said, “M100 is a great resource for every microbiology laboratory that performs antimicrobial susceptibility testing.  Each year, M100 provides susceptibility breakpoints for recently introduced antibiotics and updated or revised breakpoints for older antibiotics based on the latest scientific information.  M100 also provides the latest information on methods for detecting newer resistance mechanisms.  Every microbiology lab should have the latest edition of M100.”

M02 covers the current recommended methods for disk susceptibility testing and criteria for quality control testing and includes the M02 Quick Guide. M07 covers reference methods for determining minimal inhibitory concentrations of aerobic bacteria by broth macrodilution, broth microdilution, and agar dilution. M100 includes annually updated tables for M02, M07, and M11.  

M02, 13th ed. Includes: 

  • Clarified definitions for breakpoint, interpretive category, and susceptible.
  • Reorganized and clarified information for staphylococci. 
  • Current recommended methods for disk susceptibility testing and criteria for quality control testing.

M07, 11th ed. Includes:  

  • Photographs of growth control examples and interpretation of skipped wells.
  • Reference methods for determining minimal inhibitory concentrations of aerobic bacteria. 

In addition to publishing these three documents, on Wednesday, February 20, 2019, 1:00–2:30 PM Eastern (US) Time and Thursday, February 21, 2019, 3:00–4:30 PM Eastern (US) Time CLSI will host the Annual AST Updates Webinar. This webinar will focus on changes and updates to M100 followed by a question and answer session.  For more information and to register, visit https://clsi.org/standards/products/microbiology/education/astupdate2019wr/.

For more information about M100, M02, and M07, contact Patrick McGinn at pmcginn@clsi.org or +1.484.588.5933.   


CLSI sets the standard for quality in medical laboratory testing. A not-for-profit membership organization, CLSI brings together the global laboratory community for the advancement of a common cause: to foster excellence in laboratory medicine. 

For over 50 years, our members, volunteers, and customers have made CLSI a respected, transformative leader in the development and implementation of medical laboratory testing standards. Through our unified efforts, we will continue to set and uphold the standards that drive quality test results, enhance patient care delivery, and improve health care around the world. 

By using CLSI standards, laboratorians can improve process quality, speed the development of standard operating procedures, and implement safer practices with greater ease and efficiency. 

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