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CLSI Blog Articles

Read the latest articles about CLSI and laboratory standards in the official CLSI Blog. Browse our most recent blog articles below.

Imipenem-Relebactam and Aztreonam-Avibactam: What Do Clinical and Public Health Microbiologists Need to Know?

Novel antimicrobial agents like imipenem-relebactam (IMR), aztreonam-avibactam (AZT-AVI), and cefiderocol have been recently added to the antimicrobial armamentarium to combat multidrug resistant gram-negative infections. Guidelines for clinical microbiology laboratories regarding cefiderocol were addressed in the July 2020 CLSI AST News Update and included questions a laboratory should consider when deciding how to approach testing of these new agents. This current issue provides an update on IMR and AZT-AVI. AZT-AVI will be discussed in terms of in vitro testing and its investigational use for specific multidrug-resistant organisms (MDROs) as it is not currently US Food and Drug Administration (FDA)-approved for clinical use.

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Re-Exploring the Intermediate Interpretive Category

Clinical breakpoints provide an interpretation of the probability of treatment success, based on the MIC value or the area of growth inhibition by disk diffusion. Isolates with results within the susceptible category are predicted to be associated with a high chance of treatment success when the patient is administered that antimicrobial, whereas those in the resistant category are associated with low chance of treatment success.

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Will Your Lab be Ready for the Next Public Health Emergency?

When the COVID-19 pandemic hit full-force during March of 2020 and emergency use authorized (EUA) tests became available for measuring SARS-CoV-2, was your laboratory ready? Did you know what you needed to do before implementing the new tests? At CLSI, we know that time period was (and may still be) difficult and stressful for your laboratory, with many unknowns. To help you prepare for the next emergency event, we brought together a working group of experts to consolidate information on implementing such new laboratory tests.

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Standardization of Veterinary Susceptibility Testing

Not all laboratories use CLSI or other available standards for interpretation of veterinary culture specimens. However, if a laboratory does not adhere to a public standard, such as CLSI’s, breakpoints may vary and interpretation may be inconsistent from laboratory to laboratory, or among different regions of the country.

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The Importance of Proper Collection of Capillary Blood Specimens

The latest edition of CLSI’s GP42 standard—Collection of Capillary Blood Specimens, provides guidance for proper capillary blood collection procedures and processes to ensure the safety of the patient as well as the health care professional responsible for blood specimen collections.

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Detection and Culture of Fungi in Clinical Specimens

There has been an enormous increase in the frequency and severity of fungal infections in recent years. Culture from a clinical sample is the gold standard for diagnosis of fungal infection as it has the advantage of yielding the specific etiological agent if positive. Moreover, culture allows for susceptibility testing.There has been an enormous increase in the frequency and severity of fungal infections in recent years. Culture from a clinical sample is the gold standard for diagnosis of fungal infection as it has the advantage of yielding the specific etiological agent if positive. Moreover, culture allows for susceptibility testing.

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How Using CLSI’s M100 Helps the Fight Against Antimicrobial Resistance

In March of this year CLSI will publish the 31st Edition of M100. M100 contains the antibiotic breakpoints that help medical laboratorians throughout the world provide accurate test results to health care providers. These breakpoints aid laboratorians in selecting the most appropriate and effective antimicrobial treatments for patients.

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