This implementation guide is essential for medical laboratories aiming to ensure the highest standards of patient care. It details the minimum procedures necessary to verify the comparability of patient results across a health care system, ensuring consistency and reliability in diagnostic testing. The guide also includes a valuable link to the CLSI workbook EP31-Ed-WB, Verification of Comparability of Patient Results Within One Health Care System Workbook, which offers practical tools and resources to streamline the verification process.