CLSI C42

Erythrocyte Protoporphyrin Testing, 1st Edition

This document contains recommendations for the measurement, reporting, and interpretation of erythrocyte protoporphyrin using hematofluorometric and extraction measurement methods.

This document is available in electronic format only.

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Chairholder: Noel V. Stanton

Date of Publication: January 11, 1996

Order Code PDF: CLSI C42AE
ISBN Number: 1-56238-306-X

Order Code Print: print not available

Edition: First

Pages: 58

CLSI C42 Additional Details

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The U.S. Food and Drug Administration (FDA) has evaluated and recognized this approved-level consensus guideline for use in satisfying a regulatory requirement.

This document was formerly sold under the code T/DM09.

This archived document is no longer being reviewed through the CLSI Consensus Document Development Process. However, this document is technically valid as of September 2016. Because of its value to the laboratory community, it is being retained in CLSI’s library.

CLSI C42 Abstract

Erythrocyte Protoporphyrin Testing; Approved Guideline (CLSI document C42-A) is a comprehensive document for use by laboratorians who perform erythrocyte protoporphyrin (EP) determinations; its aim is to reduce/eliminate the lack of uniformity in current measurement practices. The biochemistry and pathology of EP are discussed, the history of EP determinations is summarized, and the applications of the test are defined. The document recommends the adoption of a specific molar absorptivity constant for the standardization of EP methods and the universal adoption of reporting units expressed as the molar ratio of protoporphyrin to heme. Detailed methods for the measurement of EP by extraction and hematofluorometry are included, and the interpretation of EP results is discussed.