CLSI C48

Application of Biochemical Markers of Bone Turnover in the Assessment and Monitoring of Bone Diseases, 1st Edition

This guideline provides information on how biochemical markers of bone turnover can be applied to facilitate and harmonize data interpretation and to help answer clinical questions in the area of bone diseases.

This document is available in electronic format only.

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Chairholder: Hubert Vesper, PhD

Date of Publication: July 1, 2004

Order Code PDF: CLSI C48AE
ISBN Number: 1-56238-539-9

Order Code Print: print not available

Edition: First

Pages: 56

CLSI C48 Additional Details

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A NCCLS-IFCC joint project.

This archived document is no longer being reviewed through the CLSI Consensus Document Development Process. However, this document is technically valid as of September 2016. Because of its value to the laboratory community, it is being retained in CLSI’s library.

CLSI C48 Abstract

Bone markers are useful tools for the management of bone diseases, because they provide information that is different but complementary to bone mineral density (BMD) measurement. Problems in the measurement and interpretation of bone marker values are still hampering the optimal utility of this clinical tool. Most of these difficulties originate from problems related to the handling and control of analytical and biological variability of bone marker measurements. These sources of variability can be substantial and need to be controlled. In this context, certain applications of bone marker testing may have different requirements for the handling and control of these sources of variability. Finally, certain bone markers or bone marker tests may require special considerations, such as analyte stability. This document addresses these issues and provides information related to applications of bone marker measurements.