CLSI M26

Methods for Determining Bactericidal Activity of Antimicrobial Agents, 1st Edition

This guideline contains procedures for determining the lethal activity of antimicrobial agents.

This document is available in electronic format only.

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Chairholder: James H. Jorgensen, PhD

Date of Publication: September 1, 1999

Order Code PDF: CLSI M26AE
ISBN Number: 1-56238-384-1

Order Code Print: print not available

Edition: First

Pages: 32

CLSI M26 Additional Details

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This archived document is no longer being reviewed through the CLSI Consensus Document Development Process. However, this document is technically valid as of September 2016. Because of its value to the laboratory community, it is being retained in CLSI’s library.

CLSI M26 Abstract

Established laboratory methods that can assess the bactericidal activity of an antimicrobial agent are needed, both because of the increase in the number of patients who do not have completely normal host immune defenses and because of the new classes of antimicrobial agents that have been introduced. Clinical cure depends largely upon host factors. Bactericidal tests can provide a rough prediction of bacterial eradication. It should be noted, however, that other factors (e.g., postantibiotic effect and the growth-inhibitory effects of sub-MIC concentrations of antibiotics) may also impact bacteriologic response of patients. The special susceptibility tests that assess lethal activity are not routinely applied to all microorganisms, but are applied in unusual situations; e.g., endocarditis. Uniform test procedures are thus needed to permit comparison of different datasets.