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Evaluation of Commutability of Processed Samples, 4th Edition

This document provides guidance for evaluating the commutability of processed samples by determining if they behave differently than unprocessed patient samples when two quantitative measurement procedures are compared.

This edition of the document was corrected in August 2022. Read the full correction notice here, and learn more about our corrections processĀ here.

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Chairholder: Karl DeVore, BA, SSBB

Date of Publication: July 14, 2022

Order Code PDF: CLSI EP14Ed4E
ISBN Number: 978-1-68440-157-4

Order Code Print: CLSI EP14Ed4
ISBN Number: 978-1-68440-156-7

Edition: Fourth

Pages: 64

CLSI EP14 Abstract

Clinical and Laboratory Standards Institute document EP14—Evaluation of Commutability of Processed Samples was developed for manufacturers and providers of proficiency testing or external quality assessment programs, although it is useful to clinical laboratories as well. The document helps users 1) determine whether noncommutability is the source of unexpected results that are sometimes observed with processed samples when two quantitative measurement procedures are compared, 2) display the magnitude of the effects, and 3) ensure that laboratory performance is evaluated fairly if noncommutability is present. The suggested protocol was developed using unprocessed patient samples as the standard of comparison.