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CLSI NBS01

Dried Blood Spot Specimen Collection for Newborn Screening, 7th Edition

This standard highlights specimen collection methods, discusses acceptable techniques for applying blood drops or aliquots to the filter paper section of the specimen collection device, and provides instructions on proper specimen drying, handling, and transport to ensure quality specimens are consistently obtained for newborn screening analysis.

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Details

Chairholder: Victor R. De Jesús, PhD

Date of Publication: April 16, 2021

Order Code PDF: CLSI NBS01Ed7E
ISBN Number: 978-1-68440-109-3

Order Code Print: CLSI NBS01Ed7
ISBN Number: 978-1-68440-108-6

Edition: Seventh

Pages: 96

CLSI NBS01 Additional Details

A standard for global application developed through the Clinical and Laboratory Standards Institute consensus process.

CLSI NBS01 Abstract

Clinical and Laboratory Standards Institute standard NBS01—Dried Blood Spot Specimen Collection for Newborn Screening provides descriptive, stepwise processes and procedures for collecting blood spot specimens for newborn screening. This standard was developed and continues to be updated to promote uniform practices for demographic newborn data and specimen collection. This standard informs and instructs health care professionals who collect and submit dried blood spot specimens on procedures for skin puncture and pain management; application of blood collected by heelstick directly onto the preprinted circles of the filter paper; blood source recommendations and other blood spot specimen collection techniques; filter paper, handling, and mailing package specifications; specimen collection device specifications; handling blood spots collected on filter paper for DNA and/or RNA analysis; and storage and retention of residual specimens. An expanded appendix section provides additional images and descriptions of unacceptable blood spot specimens.