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CLSI NBS04

Newborn Screening by Tandem Mass Spectrometry, 2nd Edition

The goal of newborn screening (NBS) testing is early diagnosis and treatment that will likely prevent or reduce the severe medical outcomes that occur in undiagnosed or untreated infants. Learn about the use of tandem mass spectrometry for NBS laboratory testing.

This reaffirmed document has been reviewed and confirmed as suitable to remain published without revision to content, as of June 2022. The document’s next scheduled review is generally five years after the reaffirmation date.

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Details

Chairholder: Víctor R. De Jesús, PhD

Date of Publication: May 26, 2017

Order Code PDF: CLSI NBS04Ed2E
ISBN Number: 1-56238-819-3

Order Code Print: CLSI NBS04Ed2
ISBN Number: 1-56238-818-5

Edition: Second

Pages: 108

CLSI NBS04 Additional Details

This document was formerly sold under the code ILA32.

CLSI NBS04 Abstract

Clinical and Laboratory Standards Institute guideline NBS04—Newborn Screening by Tandem Mass Spectrometry describes best practice procedures for specimen and reagent preparation, instrument and analyte calibration, method validation, QA and QC, run acceptance criteria with multianalyte platforms, external treatment effects on test results (eg, transfusions and total parenteral nutrition), results interpretation and reporting, follow-up recommendations, and the use of tandem mass spectrometry for second-tier testing.