Wayne, Pennsylvania, USA—The Clinical and Laboratory Standards Institute has published C49—Analysis of Body Fluids in Clinical Chemistry. This guideline provides guidance to medical laboratories for the appropriate application of measurement procedures for body fluid testing and for reporting results. This guideline primarily focuses on the recommended practice for verification of measurement procedures for measurands in body fluids and is applicable for laboratory testing requests on body fluids that do not have performance claims in the manufacturer’s package insert or an equivalent validated laboratory-developed test.
This guideline replaces the previous edition, published in April 2007. This second edition of C49 provides medical laboratories with a strategy to evaluate method performance, as well as guidance on which measurands have clinical relevance when measured in body fluid matrixes. Several changes were made in this edition.
C49 includes information on:
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